Essentiale forte for dogs: instructions, dosage and reviews

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Liver disease can overtake your cat suddenly, bringing great discomfort to the animal and the owner. However, modern medicine is directing all its efforts to cure such serious diseases as cirrhosis and fibrosis of the liver, as well as various forms of hepatitis. For this, veterinarians often prescribe Essentiale for cats. How to use this medicine and how to give it to your pet? Details in this article.

Instructions for use: dosage, contraindications

How to give Essentiale?
Dogs are given Essentiale Forte three times a day, one capsule for three months. However, in the first week of treatment, it is better to administer the drug intravenously in the form of a solution of one ml per injection. Only from the second week is it better to switch to capsules. They are best given immediately before meals. If necessary, the course of treatment can be repeated or continued. Only in the form of an injection solution, the drug is used for hepatitis, liver cell necrosis, toxic liver damage, hepatic coma, and postoperative treatment.

Only capsules can be given for chronic hepatitis in dogs or fatty liver degeneration. There are no contraindications when using Essentiale Forte.

Side effects of Essentiale Forte for dogs

When taking high doses, gastrointestinal upset in the form of diarrhea may very rarely occur, which disappears when you stop taking the drug or significantly reduce its dosage.

The drug is prescribed with caution to pregnant and lactating bitches, as well as puppies up to 2 months, since the drug contains benzyl alcohol.

Reviews from dog owners

Maria, St. Petersburg. I found my Jerrick on the street, he is a hereditary nobleman. Among the bad habits that we cannot overcome, he still has the habit of begging on the street. One day he ate some kind of rubbish and became seriously poisoned. Now all the worries are over, Jerry was saved. But the liver suffered the most. The doctor prescribed a long course of Essentiale Forte. I can say for sure that this medicine literally saved my dog, although I had to take it for a long time.

What is

Essentiale is a complex of phospholipids obtained from soybeans. Available in injection form and in capsules, which have slightly different compositions.

In addition to phospholipids, the solution contains deoxycholic acid and riboflavin, which also have a hepatoprotective effect. Benzyl alcohol and sodium hydrochloride are included as excipients.

The capsules contain castor oil, solid fats, and extracts obtained from soybeans. These substances regulate stool and cleanse the dog's intestines of toxins, which is very important for liver diseases.

Essentiale forte capsules contain α-tocopherone as an antioxidant. They also contain other excipients. How does the drug work on dogs? With various pathologies of the liver, the cells of the organ begin to destroy. First of all, membranes are destabilized; the main structural substance is phospholipids. As a result, the level of liver enzymes in the blood increases, and the detoxification function of the organ suffers.

Those that are included in essentiale are completely identical in the structural features of a dog’s liver.

They exhibit greater biological activity than conventional endogenous substances, as they contain many polyunsaturated fatty acids. They are embedded in the membrane of liver cells, preventing their destruction and stimulating regeneration.

As a result, the level of enzymes in the blood decreases, the liver begins to cope with its tasks, and the dog feels good. The drug improves the detoxification function of the liver, the process of protein and urea synthesis in this organ.

Due to the regeneration of hepatocytes, fibrotic changes in the liver are reduced. This prevents the development of cirrhosis in dogs.

The components of Essentiale Forte help normalize the condition of bile and prevent the formation of stones. They also affect the overall metabolism in the body.

When is the medicine prescribed?

Veterinarians prescribe for the following pathologies:

Acute and chronic hepatitis
Toxin damage
Cirrhosis
Fatty organ degeneration
Changes in the liver associated with heart pathology in old dogs
Prevention of lesions during treatment with toxic drugs (anti-inflammatory drugs, long-term antibiotic therapy, chemotherapy, recovery after surgery).

Side effects from the use of Essentiale are rare. Some dogs may be allergic to the components of the medication, rash, or itchy skin. Sometimes gastrointestinal disorders are observed - vomiting, diarrhea, loss of appetite.

What are the contraindications to the use of the medicine? It is not allowed for pregnant or lactating dogs, puppies under two weeks of age.

How to give

The medicine is produced in injections (5 ml bottles) and in capsules of 300 mg. Instructions for use recommend that in severe cases, starting therapy with intravenous administration of essentiale.

Analogues of Essentiale Forte for dogs

This drug is not the only hepatoprotector. To restore liver cells and maintain its functions, you can use other means, based on price or effectiveness.

Essliver Forte is a budget analogue of Essentiale Forte.

But it is important to remember that medications should be prescribed by a doctor, because each of them has differences and features:

Karsil is a popular analogue. Also contains phospholipids, made from plant components of milk thistle fruit. More often prescribed for toxic lesions, but less effective as a regenerating agent.
Essliver Forte . In addition to phospholipids, it also contains B vitamins. It is a cheaper analogue, but requires a long course of treatment due to the reduced content of the active substance.
Result Pro . In terms of composition, it is closest to Essential Forte N of all its analogues. Attracts with its lower price.
Prohepar . Multicomponent hepatoprotector with a natural biological composition. The main active substance is an extract from cattle liver.

Instructions for use of the drug Essentiale N (capsules and ampoules) in humans, dogs and cats

VetConsultPlus Information portal Therapy

Brief characteristics of the drug

Drug name: Essentiale N

Name in Latin: Essentiale N

Active ingredient: soy essential phospholipids Pharmacological group: hepatoprotector, cytoprotector Subject of application: humans, dogs, cats and other types of mammals

Where to buy: medical pharmacies Release form: solution for intravenous injection in ampoules of 5 ml (250.00 mg of 3-sn-phosphatidyl choline), capsules of 300 mg Physical properties: yellow solution, transparent, easily foams; bright yellow, almost brown powder

Release form

Two forms of the medicinal substance "Essenzale N" are available:

Injection form. Solution for intravenous injection in ampoules of 5 ml. Contains the active substance: essential phospholipids, which are phosphatidylcholine isolated from soybeans, a dried extract that consists of 93% 3-sn-phosphatidylcholine in a dose of 250 mg. There are also excipients: deoxycholic acid - 126.5 mg; sodium chloride - 12 mg; benzyl alcohol - 45 mg; riboflavin - 0.5 mg; sodium hydroxide - 13.4 mg; water - up to 5 ml.
Capsules containing as an active ingredient: essential phospholipids, which are phosphatidylcholine isolated from soybeans, which contains 76% 3-sn-phosphatidylcholine in a dose of 300 mg. Excipients: soybean oil - 36.0 mg; solid fat - 57 mg; castor oil - 1.6 mg; ethyl vanillin - 1.5 mg; ethyl alcohol 96% - 8.1 mg; alpha tocopherol - 0.75 mg; 4-methoxyacetophenone - 0.8 mg. The capsule contains: gelatin - 67.945 mg; titanium dioxide - 0.83 mg; water - 11.495 mg; iron oxide black (dye) - 0.332 mg; iron oxide yellow (dye) - 2.075 mg; sodium lauryl sulfate - 0.125 mg; iron oxide red (dye) - 0.198 mg.

How to use the drug correctly

As the instructions for use indicate, “Essentiale” in ampoules is a solution that is used for intravenous administration and contains the same amount of phospholipids - two hundred and fifty milligrams in each ampoule. The solution for injection is administered only intravenously. Under no circumstances should it be administered intramuscularly or subcutaneously, as this is likely to cause irritation.

An adult can be given two ampoules at once. Against the background of mild or moderate severity of various diseases for which Essentiale was prescribed, the solution should be administered one or two ampoules per day. If the person’s condition is severe, the dosage should be doubled. The maximum possible single dose for adults is two ampoules, and the daily dose is four. This is confirmed by the instructions for use for the Essentiale Forte N ampoules.

For children aged three to six years, the drug is administered two milligrams of solution once a day, and children aged seven to twelve years can be given twice the daily dose. If the daily dosage includes no more than two ampoules, then they are administered at one time. When the daily dose of Essentiale is four ampoules, two of them are taken in the morning and in the evening.

Immediately before administration, it is important to dilute the solution from the ampoules in a one-to-one ratio with the patient’s blood or a solution of five percent glucose or dextrose. True, a solution of glucose and dextrose can only be used in cases where Essentiale cannot be diluted with human blood. Do not dilute this medicinal product with salt solutions, such as saline or Ringer's fluid. In addition, the drug solution cannot be mixed with other medications in the same syringe.

If “Essentiale” is diluted with a solution of glucose or dextrose, it is necessary to carefully monitor its transparency throughout the entire administration. If there is noticeable cloudiness of the substance, then it is necessary to stop its administration by removing the needle from the vein, and discard the remaining drug, while the missing amount is administered from a new ampoule.

The “Essentiale” solution is administered using the jet method; this is done slowly, at a speed not exceeding one milligram per minute. For injection, select an area with high-quality veins. The elbow crease area is best suited. True, if it is not possible to inject the solution into the veins of the elbow area, then another area is selected, for example, the back of the feet, or the hand, and so on.

Against the background of acute liver diseases, therapy lasts from one to three months, depending on the speed of the person’s recovery. In case of chronic liver damage, the course of use of “Essentiale N” in ampoules according to the instructions for use is at least six months. If necessary, treatment is repeated.

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Pharmacology Essentiale N

Pharmacological effects – hepatoprotective, cytoprotective.

Pharmacodynamics of the drug Essentiale N

Essential phospholipids are the main structural elements of the cell wall and membranes of intracellular organelles. In liver pathology, damage to the cell membranes of hepatocytes and their organelles always occurs. This phenomenon is called hepatocyte cytolysis syndrome, which is biochemically manifested by an increase in the activity of alanine and aspartic transaminases in the blood serum. This syndrome causes disruption of the activity of enzymes and receptors, leading to a deterioration in the structural and functional state of hepatocytes. Their ability to regenerate is also reduced.

The phospholipids included in Essentiale are completely consistent in their physicochemical structure with endogenous phospholipids. The activity of essential phospholipids is significantly higher, which can be explained by their higher content of polyunsaturated fatty acids. The above-mentioned high-energy molecules are integrated into defective areas of the membranes of the cell wall of liver cells, which helps restore the integrity of hepatocytes and stimulates their regeneration. The cis-double bonds of the polyunsaturated fatty acids that make up the composition neutralize the parallel arrangement of hydrocarbon chains in the phospholipids of cell membranes, while the structure of the phospholipids of the liver cell membranes “looses,” which leads to an increase in their elasticity and fluidity. Thanks to this, metabolism in hepatocytes significantly improves.

Essential phospholipids, which are the active ingredient of Essentiale, in the body of humans, dogs and cats have a regulating effect on the metabolism of lipoproteins by transporting cholesterol and neutral fats to the sites of their oxidation. This pharmacological effect of essential phospholipids is associated with an increase in the ability of high-density lipoproteins to conjugate with cholesterol.

The cardioprotective properties of Essentiale have been described in humans, dogs and cats.

The drug has a normalizing effect on:

on detoxification, urea-synthesizing, protein-synthesizing functions of the liver
on the preservation and restoration of phospholipid-dependent enzyme systems and the cell wall of hepatocytes, which inhibits the formation and proliferation of fibrous connective tissue in the liver
metabolism of proteins and lipids
due to the release of phospholipids into the bile, the lithogenic index is significantly reduced, which leads to the stabilization of bile and the prevention of cholelithiasis

Pharmacokinetics of Essentiale

In the body of humans, dogs and cats, phosphatidylcholine enters hepatocytes, and it is conjugated with high-density lipoproteins.

The half-life of the choline component is about 66 hours, and the polyunsaturated fatty acids are about 32 hours.

Method of using essentiale in humane medicine and its dose to humans

The drug is used in the form of intravenous injections. It is undesirable to inject this drug intramuscularly, which is due to the development of local reactogenic reactions (the drug irritates soft tissues and causes an inflammatory reaction). The standard dose of Essentiale for humans is 5–10 ml (1–2 ampoules). For severe forms of hepatopathy, use 10–20 ml (2–4 ampoules) per day. The contents of 2 ampoules (10 ml) can be administered intravenously at a time. The drug can be used twice a day. It is strictly forbidden to mix essential phospholipids in the same syringe with other medications. It is recommended to dilute the drug with the patient’s blood in a 1:1 ratio (using autologous blood).

If necessary, the drug is diluted with only a 5-10% glucose solution, and the diluted drug solution should be transparent throughout the entire time of intravenous injection.

It is strictly forbidden to dissolve the drug with electrolyte solutions (isotonic nitride chloride solution, Ringer's solution, etc.).

It is recommended to supplement intravenous administration with oral forms of the drug as quickly as possible.

The drug is also used orally. Capsules of the drug must be swallowed whole and washed down with a sufficient volume of water (about 200 ml).

For adults and adolescents over 12 years of age, take 2 capsules 3 times a day with meals. The duration of use of Essentiale is not limited (determined by the attending physician).

Oral, subcutaneous or intravenous?

Essentiale is available in capsules and as an injection solution. Has a transparent or yellow color. The action of the injection is always faster than capsules, but the dog owner can choose how it is more convenient for him to give the medicine to the dog.

In order for the liver to fully recover, a fairly long course of taking Essentiale is required. If the animal is in a serious condition, using the product by ingestion may cause vomiting.

After surgery, in severe conditions, toxic damage to the body, cell necrosis and other pathologies, this drug is prescribed in the form of intravenous injections. For hepatitis and fatty liver, taking the medicine only orally is permissible.

Contraindications to the use of Essentiale

According to the instructions for use of the drug "Essentiale", a number of contraindications have been established:

allergic reactions
children under three years of age
allergy and hypersensitivity to any of the ingredients of the drug

Essentiale is used with caution during pregnancy, since the drug contains benzyl alcohol, which penetrates the hematoplacental barrier quite well. Clinical studies have established that the use of drugs containing benzyl alcohol in newborns with a high frequency of developing dyspnea syndrome with a fatal outcome.

Side effects on the drug Essentiale

In humans, dogs and cats, side effects on Essential are extremely rare. The following side effects are described:

allergies (urticaria)
delayed type hypersensitivity
diarrhea
nausea
bitter taste in the mouth
itching
skin rash
a soft chair
stomach discomfort

special instructions

Only use a clear solution. Foaming may occur when using the drug.

Release form

Ampoules with a solution for intravenous injection, 5 ml each, containing 250 mg of essential phospholipids. Ampoules of 5 ml (dark glass).

Capsules that contain 300 mg of active substance.

Manufacturer

FamarHealthCareServices (Madrid, Spain). Address: Avenida de Leganes, Alcocorn (Madrid), Spain.

Storage conditions for the drug "Essentiale N"

Store out of the reach of children, namely in the refrigerator at a temperature of 2 to 8 °C.

Expiration date of the medicine

According to the instructions for use for humans, dogs and cats, the shelf life is three years. The drug should not be used after its expiration date.

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Interaction of Essentiale with other drugs

The therapeutic effect of all varieties of Essentiale is determined by the phospholipids included in its composition. Vitamins in the composition of the drug can not only enhance the effects of these important components, but also replenish their deficiency in organs and tissues. Thus, vitamins play a significant role in the main therapeutic effect of the drug in question.

To begin with, we note that phospholipids, which are part of Essentiale, normally act as substances that make up the structure of the cell membrane. Phospholipids themselves are complex organic compounds that have a short “head” of phosphatidylcholine and long tails of unsaturated fatty acids, such as linolenic and oleic.

Thus, phospholipids are arranged in a certain row with their “tails” in the direction of one side, and their “heads” in the direction of the other. After this, two similar rows are connected to each other by “tails” in such a way that their “heads” turn out to be facing the inside of the cell, that is, into the cytoplasm, and the second part is turned into the region of the intercellular space. This is indicated in the instructions for use for “Essentiale” in ampoules. It is important to note that cats can also be given this drug.

Thus, phospholipids are required for the structure of cell membranes in the human body. If there are not enough of them, the membranes will be fragile, as a result of which substances they do not need can get into the cells, which will provoke their death. The result of membrane damage is premature cell death. This is confirmed by the instructions for use for “Essentiale” in ampoules. The description of the drug's action can be continued.

Due to the fact that phospholipids, after absorption in the intestine, end up primarily in the liver, this is where they are integrated into membranes, improving their properties and normalizing their structure. The hepatoprotective effect of the drug “Essentiale Forte” in ampoules consists of improving the quality of cell structure, as well as increasing their endurance. The instructions for use also describe these features of the drug.

Due to its positive effect on cell structure, the drug reduces the number of dead liver elements. This helps to normalize the functioning of the organ, creating all the prerequisites for its effective operation in the future. In other words, “Essentiale” seems to prolong the vital activity of cells, ensuring improved liver function for a very long period, until the supply of phospholipids runs out and the necessary elements begin to die again in large quantities.

Against the background of the use of the drug in question, there is a normalization of laboratory indicators of liver function due to hepatitis, fatty degeneration, cirrhosis, and, in addition, the resistance of cells to toxic effects increases. In addition to the normalization of indicators, under the influence of the drug "Essentiale" in ampoules (according to the instructions for use), the severity of necrosis, as well as inflammation occurring in the liver tissues, is reduced.

Thus, the effects that the drug has on the liver are expressed in the following results:

The integrity of the liver cell membrane is restored.
The normal integrity of the liver cell membrane, as well as its structure, is maintained.
The work of membrane enzymes is activated, which ensure the transport of various substances both into the interior of the cell and out.
Lipid and protein metabolism improves.
The reserves of glycogen accumulated in the liver increase.
The detoxification function of the liver improves, that is, the liver’s ability to neutralize all kinds of toxic substances, in particular medications, increases. This is confirmed by the instructions for use and reviews for the drug “Essentiale” in ampoules.
There is a process of converting cholesterol and other fats that can cause atherosclerosis into other less dangerous forms, which are easily eliminated thanks to cells designed to produce energy.
The liver's need for excess energy is reduced.
Fatty infiltration of hepatocytes is reduced or completely eliminated.
The risk of sclerosis, fibrosis and cirrhosis of the liver is reduced.
The chemical and physical properties of bile are normalized, during which its lithogenicity, that is, the ability of bile to form stones in the bladder, is reduced.

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In addition to the positive effects on the liver, all varieties of the drug “Essentiale Forte” in ampoules (the instructions for use confirm this) can have the following effects on other organs and systems of the body:

The size and total number of atherosclerotic plaques are reduced due to the normalization of the volume of lipoproteins of both high and low density in the blood thanks to “Essential” in ampoules. The instructions for use also mention this important property of the medicine.
The fluidity of the blood is normalized, which reduces its viscosity against this background.
Cholesterol is removed from atherosclerotic plaques.
The severity of clinical signs of diabetes mellitus is reduced.

The good tolerability of the drug "Essentiale" makes it possible to recommend it for use not only to improve the quality of functions along with the condition of the liver, but also as a general strengthening agent, which significantly increases the body's resistance to certain diseases.

Since all varieties of Essentiale contain phospholipids, which are obtained from natural soybeans, theoretically they can provoke certain allergic reactions. Patients prone to this should be careful when using Essentiale. At the first manifestations of allergic reactions, you must immediately stop using the drug and consult your doctor.

The solution contains some ethyl alcohol, which is used in the process of extracting phospholipids from the beans. The amount of ethyl alcohol content is insignificant and does not cause any reactions that are characteristic of alcohol. During the entire period of therapy, it is important to refrain from consuming any substances that are harmful to the liver, such as alcohol, drugs, and so on. This is indicated in the instructions for use for the “Essentiale” product in ampoules. Contraindications must be taken into account.

Against the background of chronic hepatitis, the drug can be used only if the person’s condition improves. For children, it is prohibited to use ampoule solutions for intravenous administration up to three years of age. The ban on use at such a young age is due to the content of benzyl alcohol in the product, which can provoke the formation of Haspings syndrome with subsequent death. What else does the instructions for use for Essentiale N in ampoules tell us?

The medication is generally well tolerated and rarely causes any side effects, however, if any occur, you should immediately stop using this drug and consult your doctor.

Side effects of ampoule solutions used for intravenous injections include the following symptoms:

Allergic reactions of the body, such as various rashes, itching and exanthema along with urticaria.
The appearance of irritation in the injection area.
Diarrhea due to the use of large dosages of ampoule solution.

An ampoule solution for intravenous administration is capable of interacting with anticoagulants, that is, substances that reduce blood clotting, while enhancing their effect. For this reason, it is advisable to reduce the dosage of the anticoagulant when using these products simultaneously.

How to give Essentiale to a cat?

People love animals, enjoy them and care for them. They, in turn, give their owners signs of greeting, wagging their tails or quietly purring. But there are times when wards get sick and require special attention. Sooner or later, the owner is faced with the problem of how to “feed” medicine to his pet. Or this has to be done for preventive purposes. For many, such a simple task causes trouble. Although, once learned, this procedure is carried out quickly and painlessly.

Cats are categorically against tablets, capsules and drip medications. To force the “purr” to take medicine, the owners resort to various tricks and wisdom. However, in fact, you should remember a few rules and use valuable tips. For example, how to properly treat an animal and how to give Essentiale to a cat, because this drug is in capsules.

Of course, the reaction of your pet cat to all possible methods of treatment will be aggressive and cause a negative reaction. Therefore, you should be patient and persistent while treating your animal. To begin with, you can try introducing the capsule into your cat’s favorite food. Or carefully mix the medicine with a small amount of food. If such actions are in vain, then you will have to resort to more stringent measures, first cutting the drug capsule in half. All the powder should be poured into one half of the capsule, and the other half should be cut in half again. Carefully fasten the two halves together, and the capsule will come out smaller in size. The dosage of Essentiale for cats is prescribed by an experienced veterinarian. This may be taking one capsule every 10 days or more often.

You should choose the right time to take the medicine. For example, when the animal is half asleep, simply force the cat to open its mouth slightly, while placing the index and thumb behind the fangs, and clasping the muzzle from above with the hand. Tilt the animal's head up and place the medicine on the root of the tongue. Close your mouth and gently stroke the cat's neck towards the esophagus, which will facilitate a painless process of swallowing the drug. Afterwards you can give him some water to drink.

If the animal is restive, then it is better to wrap it in a towel, leaving only its face outside. This way the cat won't be able to scratch. It is necessary to accustom the cat to taking medications in advance, sometimes instead of a pill, give a small piece of solid food.

Treatment of hepatitis in an older dog

I really liked the article about hepatoprotectors, maybe it will be useful (if not, write and I will delete it) Hepatoprotectors - a history of misconceptions. Or how to protect your liver Only in the countries of the former USSR are various hepatoprotectors actively used by both doctors and fellow citizens in the hope of healing the liver with one magic pill. Unfortunately, simple ways don't work. I will try to answer some common questions, based on the facts of evidence-based medicine, but doing it in simple non-scientific language: - when are hepatoprotectors needed at all - various miracle drugs that “help the liver” - to drink or not to drink: - Essential phospholipids - milk thistle preparations (silymarin ) - ademetionine - ursodeoxycholic acid - metadoxyl - ornithine aspartate (Hepa-Merz) the liver recovers very quickly - it has fantastic regeneration. Remember the myth about Prometheus - the eagle pecked his liver every day, and by morning it grew back. Keep in mind that the liver never hurts - well, there are no pain receptors there, so signs of the disease usually appear only at the stage of advanced cirrhosis, when it is too late to drink Borjomi. Another important consequence: if you worked hard all week at work, and on Friday you relaxed with friends and, with a friendly conversation, persuaded a liter of Scottish whiskey - YOU DO NOT NEED TO TAKE ANY LIVER PILLS - everything will be fine with her. Take better care of taking headache pills and drinking plenty of fluids. - the liver capsule can hurt - this is the outer shell of connective tissue. When there is a blow to the liver, the latter often ruptures and a hematoma (internal bleeding) occurs, which compresses the surrounding tissues and nerves - hence the pain. When hepatitis occurs, the liver almost never hurts. Only if it increases greatly, then this very capsule stretches and pain occurs. When are hepatoprotectors needed? In general, the class of drugs known as hepatoprotectors exists only in the former USSR. Most drugs are not even registered in Europe and the USA. Some are used for narrow indications. Most often in the world, all these essentials and heptrals are registered as dietary supplements. Those. Drink it if you want, or don’t drink it, there will be no harm, but no benefit either. So, briefly, when a doctor can prescribe a drug: - alcoholic hepatitis or cirrhosis - hepatoprotectors are in addition to the main treatment - YOU MUST STOP DRINKING. Otherwise, take pills or don’t eat, neither will help. - non-alcoholic fatty liver disease - in fat people and people with type 2 diabetes, fat is deposited in the liver. In a simplified form, the fat in the liver cells begins to oxidize and destroy them. The main approach to treatment: weight loss, physical activity, cholesterol reduction, antidiabetic drugs (Siofor, etc.) Hepatoprotectors are prescribed to achieve an effect more quickly. - chronic viral hepatitis - hepatoprotectors are prescribed for the prevention of cirrhosis ONLY IF antiviral therapy FAILS or IS NOT POSSIBLE. There are also a number of serious diseases (primary biliary cirrhosis, drug-induced hepatitis, etc.) when individual hepatoprotectors can be prescribed, but you, my dear readers, are better off not even knowing about these diseases. The main conclusion: hepatoprotectors are prescribed as an adjuvant. Moreover, the doctor must choose it. After watching enough commercials about the adventures of a liver on legs, you don’t need to run to the pharmacy and buy all sorts of crap there... Now on to the medications. Essential phospholipids (Essentiale, Essliver, Resolut, Phosphogliv). The idea was fantastic - knowing that cell membranes are destroyed in the liver, adjust these same phospholipids so that they fit into the gaps in the cell wall. Something like this: a cannon is firing at a brick wall, and instead of foraying behind enemy lines, you bring up a string of trucks loaded with bricks. But the funny thing is that when you take the Essentiale tablet, all these “bricks” do not enter the liver, but are distributed throughout the body, where they are successfully metabolized. These are the pies with kittens! Pure bullshit - all studies have proven that they never help anyone. The last study that finally buried Essentiale and Co. was conducted in the USA on heavily drunk veterans of the Vietnam War - the result was logical: what you drink Essentiale, what you don’t drink - it makes no difference, the main thing is to drink slightly less. By the way, the French from Sanofi, the manufacturer of Essentiale, are not closing their plant only because 99% of these wheels are sold to Russia, Ukraine and other countries of the former USSR. NO ONE ELSE IN THE WORLD (even in the Republic of Chad) needs this shit. Conclusion - do not transfer money! Our doctors (especially therapists who have seen enough advertising about zombies) often like to prescribe this crap. My advice as a gastroenterologist is that at least you can save money on this component of treatment. Milk thistle drug silymarin (Karsil, Legalon, Silimar, Silibor, Hepa-Bene, etc.) This drug really works. By the way, silymarin is the only antidote (antidote) for the alkaloid of the toadstool. It’s really advisable to take it before you consume this toadstool. This is a powerful antioxidant. If necessary, it is prescribed for long-term use for at least 3 months, especially for toxic hepatitis. Slows down the progression of liver cirrhosis, which has been proven. BUT THERE IS NO POINT TO TAKE A COUPLE OF TABLETS AFTER BOOKING! Again, it is better not to save money, but to spend money on German Legalon, which contains the purest chemical substance, and not on cheap Karsil, which contains much less silymarin. Ademethionine (Heptral, Heptor). In the world it is registered as a MEDICINE only in Russia, Italy and Germany (well, also in Australia as a veterinary drug). In other countries it is a dietary supplement, because all the research failed miserably. It costs a little more than x..i. The effect is doubtful. Competent doctors know that Heptral is very effective if you drip it into a vein. But the tablets don’t do a damn thing - this is because when taken orally, only 5% of the drug is absorbed in the intestine. So, most of what you paid a lot of money for will end up in the toilet. In Russia they really like to prescribe these pills to rich alcoholics, and they really like to drink them after another binge. And the tests really are getting better. This is explained by the fact that in case of alcoholic liver disease, if you stop drinking, the tests themselves will begin to improve quite quickly - remember Prometheus. Conclusion: if, if necessary, the doctor prescribed you to “drip” Heptral, this is good, and then taking the pills is a pure transfer of money. Ursodeoxycholic acid (UDCA, Ursofalk, Urdoxa, Ursosan). A very effective drug, especially for severe liver damage. Unlike Essentiale and Heptral, it really works, which has been proven. However, I do not advise you to take it without a doctor’s recommendation. Not everyone needs it and not always. Metadoxyl. Actually it is not a hepatoprotector, but is used to relieve withdrawal symptoms in alcoholics. I am writing about it because it has a pleasant property - it enhances the metabolism of alcohol in the body. If you need to drink a lot, but don't want to get drunk, take 2-3 capsules immediately before drinking. Metadoxil will also be very useful in the morning, when you need to quickly get out of a hangover and sober up faster. But it does not protect the liver. Ornithine aspartate (Hepa-Merz). At one time he was given a lot of publicity on the radio, incl. the late Trachtenberg. HAS NO EFFECT ON THE LIVER AT ALL! THIS IS A PURE RUN FROM THE MARKETING DEPARTMENT. This drug is very effective for short-term recovery from hepatic coma, because... it binds components in the blood that are toxic to the brain. DRINKING IT TO PROTECT THE LIVER IS POINTLESS. Summary: - Essentiale, Heptral in tablets, Hepa-Merz - we drink it if we want to throw away our money. In other cases - FUCK...Y! — silymarin (Legalon) — we drink as prescribed by the doctor. We also eat 2 tablets of 140 mg each before eating questionable mushrooms (but it’s better to throw away the mushrooms) - UDCA (Ursofalk) - we drink only as prescribed by a doctor - Metaboxil - we drink if we need to get drunk slowly and dry out faster. original taken from ibigdan LiveJournal https://ibigdan.livejournal.com/11908615.html

Essentiale forte for dogs