Features and principle of operation
The drug, which has immunostimulating properties, was developed by a Russian company. It has become an excellent alternative to foreign analogues. High efficiency, wide range of applications and reasonable price are the main advantages of the drug.
The active substance of the drug is recombinant human interleukin-2. It is obtained from yeast. This substance is a protein that is involved in the production of immune system cells. The medicine stimulates the synthesis of T-lymphocytes, thereby triggering the immune system.
When using the medication, immunity increases. Individual chains of the system are activated and increase the body's ability to withstand various factors of influence. The production of one’s own antibodies prevents the spread of viral, fungal, and bactericidal infections, and also suppresses the growth of cancer cells.
Roncoleukin is produced in the form of an injection solution. Packaged in ampoules and glass bottles. 1 ml of liquid may contain different concentrations of the active substance. It is designated IU (international units) and indicates the number of units of the active ingredient. The composition also includes other components that do not have an active effect on the body:
- dithiothreitol;
- water for injection;
- ammonium carbonate;
- sodium dodecyl sulfate;
- D-mannitol
Externally it is a transparent, colorless liquid. A light yellow tint may be present.
Description
Roncoleukin for animals is an injectable immunomodulator, is a dosage form of human rIL-2 (recombinant interleukin-2), isolated and purified from yeast cells Saccharomyces cerevisiae (Baker's yeast), with the addition of the following excipients D-mannitol, SDS (sodium dodecyl sulfate) and DTT (dithiothreitol).
One ampoule contains recombinant human interleukin-2 0.05; 0.1; 0.25 or 0.5 mg (50,000, 100,000, 250,000, 500,000 IU). As excipients, 1 ml of the drug contains: D-mannitol – 2.5 mg/5 mg/12 mg/25 mg/50 mg, sodium dodecyl sulfate – 0.5 mg/1 mg/2.5 mg/5 mg/ 10 mg, dithiothreitol – 0.08 mg, ammonium carbonate – 0.79 mg, water for injection up to 1 ml.
One bottle contains recombinant human interleukin-2 2 mg (2,000,000 IU). As excipients, 10 ml of solution contains: D-manitol - 100 mg, sodium dodecyl sulfate - 20 mg, dithiothreitol - 0.8 mg, ammonium carbonate - 7.9 mg; water for injection – up to 10 ml.
When is it appointed?
According to the instructions, Roncoleukin for dogs is used in complex therapy for the following pathologies:
- for viral infections (plague, viral enteritis, leptospirosis);
- for pathologies of bacterial origin (rhinitis, purulent wounds, otitis, bronchitis);
- for fungal diseases (lichen, microsporia);
- for cancer tumors localized in different places.
The list of diseases for which Roncoleukin is used in combination with other drugs can be continued for a long time. The medicine is also prescribed:
- to improve immunity and prevent the development of viral, fungal and purulent-inflammatory pathologies;
- to eliminate the consequences of stressful situations;
- to accelerate regeneration in case of burns, fractures or other injuries;
- to enhance the effect of the vaccine and avoid possible consequences;
- to prevent postoperative complications and speed up recovery.
The medication is also indicated for old pets whose immunity is severely weakened.
Important! And although the drug is widely used in veterinary medicine, as it is highly effective, it should not be used without consulting a doctor.
Purpose
The medicine is actively used as an immunomodulator. Veterinarians prescribe Roncoleukin injections for the treatment of the following diseases:
• viral infections – plague, viral and hemorrhagic enteritis;
• diseases of a bacterial nature – otitis, rhinitis, bronchitis, infected purulent wounds and other pathologies;
• fungal diseases – lichen, microsporia, etc.;
• malignant tumors.
Roncoleukin successfully copes with diseases of the respiratory system. It is prescribed for pneumonia, bronchitis, pleurisy, and relapses of chronic diseases of the upper respiratory tract.
The medicine is prescribed:
• as a prevention of the development of fungal, viral, purulent-inflammatory diseases;
• to improve immunity;
• to accelerate tissue recovery after fractures, burns and other injuries;
• enhancing the effectiveness of the vaccine and preventing consequences after vaccination;
• accelerating the recovery of the body after surgical interventions and preventing the development of postoperative complications;
• eliminating the consequences of stress factors.
In the postoperative period, Roncoleukin will protect your pet from the development of complications and secondary infections. The medicine is administered before surgery, and the sutures and wounds heal, reducing the likelihood of inflammation and suppuration of the sutures by more than 70%.
Important! The medicine is also recommended for older pets whose immunity is weakened.
Roncoleukin is effective for the prevention and treatment of dermatological diseases. It is prescribed for both acute and chronic pathologies. Prevention will help prevent dermatitis, dermatoses, ulcers, and reduce the healing time of wounds, burns, and frostbite by almost half.
Important! When treating burns, Roncoleukin can be used as an external agent for irrigation or compresses.
Dosage
The instructions for use indicate that the dose of Roncoleukin for dogs is calculated taking into account the animal’s weight and pathology. If the drug is used for treatment, you should adhere to the following doses:
- For diseases caused by bacteria, viruses or fungi, 10,000-15,000 IU are needed per 1 kg of weight. Depending on the pet’s condition, 2-5 injections are given with an interval of 1-2 days.
- For cancerous tumors, 5 injections are given. The dose is calculated according to the scheme 15,000-20,000 IU per 1 kg of animal weight. The courses are repeated monthly.
When used for prophylactic purposes, the following regimens are followed:
- To increase the effect of the vaccine, the injection is given subcutaneously at the same time as the vaccination or one day before. For 1 kg of weight you need 5000 IU.
- To stimulate the immune system in order to prevent fungal or infectious diseases, the dose of the drug is calculated according to the same scheme. One or two injections are given with a time interval of 48 hours.
- To avoid complications of operations, the solution is injected before surgery or immediately after it. If necessary, the injection is repeated after 2 days. Dose – 5000 IU/kg.
- If the medication is used to prevent the effects of stress, which can occur during transportation, participation in an exhibition, or visiting a clinic, the injection is given 48 hours in advance at the rate of 5000 IU per kilogram of weight 2 days before exposure to the stress factor.
- To restore the immunity of old or weakened animals, the dose is calculated based on the fact that 10,000 IU is needed per 1 kg of weight. Two injections are given. The interval between injections should be 48 hours. Injections are repeated after 3-6 months.
Despite the fact that the instructions contain precise instructions on how to calculate the dose, this must be done by a doctor.
Composition and release form of the drug
Roncoleukin is a drug that is available in the form of a solution for injection and infusion, as well as intranasal, oral and external use. The yellowish or colorless liquid is packaged in small glass ampoules of 1 ml and 10 ml.
The instructions for use of the veterinary drug Roncoleukin indicate its main active ingredient - human recombinant interleukin-2, isolated from yeast cells.
Auxiliary components include sodium lauryl sulfate, ditriothreiol ammonium bicarbonate, distilled water.
Methods of application
One of the advantages of Roncoleukin is that it can be given to dogs in various ways:
- Subcutaneous injections. To the medicine in a bottle or ampoule, add 1.5-2 ml of water 0.9% sodium chloride solution. You can replace sodium chloride with water for injection. The injection should be given in the neck area.
- Intravenous administration. As in the previous case, the medication is diluted with sodium chloride solution and then administered through a dropper. This method is usually used for very sick and weakened animals.
- Oral method. The liquid from the ampoule or bottle is diluted with 10 ml of sodium chloride and then given to the animal.
Less commonly, the medication is used externally. They moisten purulent wounds and areas of inflammation. The medicine can be used for instillation into the nose or insertion into the bladder through a catheter for cystitis and other pathologies of this organ. In each of the above cases, the medicinal solution is diluted with sodium chloride.
Do not shake the ampoule with the medicine too much, as it begins to foam. The immunostimulant can be used in conjunction with antibiotics, vitamin complexes, antiviral and other drugs. The only exception is corticosteroids. They can be used together with Roncoleukin only under the supervision of a doctor.
Note! It is not recommended to administer the medication together with glucose, as it greatly reduces its effectiveness.
Basic principles of use
Roncoleukin is used in combination with other veterinary drugs in the treatment of infectious diseases of various origins (viral, bacterial, fungal). Standard application regimen: 5-10 thousand units per 1 kg of animal weight, in a course of 2-3 injections, with an administration interval of 24 hours.
In the chronic course of the disease, the recommended dose increases to 10-15 thousand units per 1 kg of weight, in a course of 5 injections. For severe inflammatory processes (purulent inflammatory processes, respiratory diseases - pleurisy, rhinitis, acute intestinal infections, etc.), it is recommended to administer 1 time per day, a dose of 10 thousand units per 1 kg of weight, in a course of 5 injections. Therapy of hereditary diseases (polycystic kidney disease in cats) the recommended dose is 20 thousand units (MU) per 1 kg of weight, a course of 5 injections. If such a need arises, the course of treatment can be repeated after 30 days. As maintenance therapy, for weakened and aged animals, it is recommended to use roncoleukin once every three months, in a course of 1-2 injections, at a dose of 5-10 thousand
One unit per 1 kg of weight, with an administration interval of 48 hours. For animals with heart disease, roncoleukin is used carefully, with an interval of 48 hours between injections. Careful use of roncoleukin is necessary for malignant processes in the blood and lymph (as decided and under the strict supervision of a veterinary specialist). Intranasal administration is possible (especially for rhinitis), as well as use in blockades (especially in the treatment of papilomatosis - introduction under the base of papilloma, stomatitis - introduction under the mucous membrane), subconjunctival administration (eye diseases - conjunctivitis, blepharitis, iridocyclitis, eye injuries, etc.) . Oncology (tumors of various locations, including: mammary gland, lymphoma, osteosarcoma - bone cancer, squamous cell carcinoma, melanoma) - a dosage of 10-15 thousand units per 1 kg of animal weight is used, a course of 5 injections, i.v. intravenous (intravenous) or subcutaneous (subcutaneous) administration. To boost immunity, subcutaneous or oral (oral) administration of roncoleukin is recommended, at a dose of 5 thousand
per 1 kg, 1-2 times, every 24 hours.
Practical Application Examples
The owners of the dog came to the reception: German shepherd, 3 years old, female.
Complaints: periodic lethargy, poor eating, swelling in the left cheekbone area. The owners suspect dental problems.
As a result of the examination, a chip was found on the molar; there was no tissue inflammation. Body temperature – 39.3 degrees.
The following course of therapy was applied - catozal, ascorbic acid 10%, antibiotic ceftriaxone, traumeel, treatment of the oral cavity with Lugol's solution with glycerin.
As a result of a week's course of treatment, the disease was partially stopped, but exacerbations occurred periodically. An x-ray was ordered, which resulted in a final diagnosis of osteomalacia of the maxilla.
Treatment: removal of a chipped molar, streptomycin - 14 days course, roncoleukin - 10 thousand. Units/kg 5 injections, traumeel, echinacea compositum, lactobacterin.
Result of treatment: the disease was completely stopped, a state of long-term remission was achieved, the animal’s condition was consistently good.
Dog, Staffordshire Terrier, male, 2 years old.
Complaints: complains about the paw, lethargy.
As a result of the examination: abscess of the left anterior bone, in the metacarpal area, septicemia, temperature -40.5 degrees.
Treatment: surgical treatment of the abscess, rinsing - furatsilin, ointment - levosin, lincomycin, traumeel, roncoleukin - at a dose of 5 thousand units per kg of body weight, 1 time per day, for a course of 3 days.
Result of treatment: the next day the animal’s condition stabilized, a week later the animal was clinically healthy.
Contraindications and side effects
The use of Roncoleukin for dogs is impossible in the following cases:
- in case of intolerance to the components of the drug;
- for heart failure and heart rhythm disturbances;
- during pregnancy.
For chronic kidney and liver diseases, the use of the medication is possible only after consultation with a veterinarian.
In case of an overdose, side effects may occur, which are manifested by increased body temperature, chills and heart rhythm disturbances. Depending on the pet’s condition, non-steroidal anti-inflammatory drugs and analeptics can be used to relieve symptoms.
Sometimes the following occurs at the injection site:
- seals;
- redness;
- soreness.
Usually the body’s reaction goes away on its own within 1-2 days and does not require special treatment.
Indications for use of Roncoleukin
The main active ingredient in Roncoleukin acts directly on T-lymphocytes. They are the ones who produce active cells that destroy entire tumor tissues and pathogenic microorganisms. It is for this reason that the drug is simultaneously an immunomodulator, anticarcinogen, antimycotic and antibiotic.
What is Roncoleukin used for?:
- treatment and prevention of oncological diseases - cancer of the gastrointestinal tract, kidneys, bones, osteosarcoma;
- purulent and trophic wounds;
- complex treatment of infectious diseases of viral origin - enteritis and distemper in dogs, calcivirosis and panleukopenia in cats;
- complex therapy of diseases of a bacterial nature - conjunctivitis, rhinitis, otitis;
- fungal infections - saprophytic fungal infections, lichen, trichophytosis, microsporia;
- prevention of complications after vaccination;
- acceleration of wound healing after surgery;
- metabolic disorders accompanied by skin rashes and lesions.
The instructions for use of veterinary Roncoleukin indicate that this drug can be used to normalize body temperature during hypothermia (low temperature), strengthen the immune system and improve the general health of adult animals.
Roncoleukin improves the functioning of internal organs - liver, kidneys, heart, pancreas, and improves blood biochemical parameters.
Important points
The medicine should be stored at a temperature not exceeding +10 degrees Celsius. A refrigerator is perfect. The drug can be transported at higher temperatures up to +25 degrees, but not more than 10 days. After opening the bottle, you can use the medicine within 2 days.
Roncoleukin should absolutely not be used to treat dogs in the following cases:
- when cloudiness, sediment or foreign impurities appear in the solution;
- after the expiration date;
- in the absence of information on the packaging about expiration dates, composition, manufacturer;
- if the seal of the bottle is broken.
There is no need to take special precautions when using an immunostimulant.
Roncoleukin for ruminants
The immunostimulant is used for therapeutic and preventive purposes.
Treatment of cattle
Roncoleukin is used in the following situations:
- Treatment and prevention of contagious diseases of bacillary and viral etiology. 1–3 hypodermal injections of 2–3 thousand IU are required. The interval between them is two days.
- Treatment of necrobacillosis. The immunocorrector is administered subcutaneously or intravenously. Dose - 1 thousand IU/kg. It is administered 2-3 times every 7-10 days.
- When infected with chlamydia, three subcutaneous administrations of the same dose at weekly intervals are effective.
- In case of ovarian dysfunction, the cow is injected with Roncoleukin twice, 500 thousand IU, every 1.5 days.
Roncoleukin is indicated for bovine necrobacteriosis
Disease Prevention
The immunocorrector is used in the following situations:
- Stimulation of the immune system of a day-old calf. 100 thousand IU are injected at a time.
- To enhance the production of antibodies simultaneously with vaccination, 1–2 thousand IU/kg.
- As an anti-stress drug two days before transportation, appraisal and other events.
Roncoleukin for MRS
Indications for the use of Roncoleukin in small ruminants are the same as in large ruminants. Dosage for adult animals - 2, young animals - 5 thousand IU/kg.
Owner reviews
Karina, owner of the Staffordshire bull terrier:
“They injected a dog with Roncoleukin for oncology. He stopped the growth of the tumor for a while, and then the veterinarian prescribed other medications that have been helping to keep our pet alive for two years now. The dog tolerated the injections of the immunostimulant well, although the doctor warned that local reactions may occur and the temperature may rise.”
Nikolay, owner of a German shepherd:
“The dog was diagnosed with osteomalacia of the upper jaw due to a chipped tooth. After the operation, a number of drugs were prescribed, including Roncoleukin. I believe that he helped Irma recover quickly and prevented possible complications after surgery. There were no side effects as a result of the use.”
Side effects from using the drug
Side effects can only be observed as a result of an overdose of the drug. In this case, an allergic reaction, skin rash, and fever may occur. With rapid administration, tachycardia is sometimes observed. Treatment in this case is symptomatic.
Thanks to its unique composition and production technology, the product has no analogues. From the list of immunomodulators that are also used in veterinary medicine, Bioleukin, Interferon, Altevir and Famvir are widely known. The use of a pharmacological synonym is allowed only in cases where the dog has an individual intolerance to the components.
Introduction rules
There are many methods of administering medication. In each case, you must follow the method of application, since otherwise the effectiveness of the medicine can be significantly reduced. To administer the drug subcutaneously, you must first dilute it with a couple of milliliters of water for injection or saline. Please note that the composition should first be warmed to room temperature.
In cases where intranasal (into the nose) administration of Roncoleukin is required, the primary solution is diluted in five milliliters of saline. The finished drops are “poured” into the nose (two or three drops per nostril), the frequency of administration is at least three to five times a day
It is important to remember that the solution should not be older than two days. After this period, the drops are prepared again
Store the solution in a household refrigerator at a temperature of 2-4 degrees Celsius.
The easiest way is with an external method of application: in this case, the entire contents of the bottle or ampoule are diluted in 10-12 milliliters of sterile saline, after which the resulting solution is used to irrigate tampons or applied directly to wounds, ulcers or similar damage to the skin. When treating severe cystitis, it is also practiced to inject the composition directly into the bladder cavity. The method is very effective and efficient.
The volume of saline solution (necessarily sterile) is selected based on the dimensions of the sick animal. You can take from 5 to 50 milliliters. Dilution of Roncoleukin is carried out with physiological solution, preheated to a temperature of 37 degrees Celsius. The resulting composition is injected directly into the cavity of the bladder, using a catheter for this purpose. This is what determines the requirement to heat the solution: cold, it can only worsen the condition of the organ, worsening the course of the inflammatory process.
It is much easier to administer the medicine orally: take 10 milliliters of purified or simply boiled water, in which the contents of the ampoule are diluted. The resulting mixture is fed to the animal. Please note that the most pronounced effect of the drug is achieved only if it is gradually poured under the tongue by drops.
Some veterinarians use the drug without getting dirty with preliminary dilution. You shouldn't do that. Even with a subcutaneous injection of a pure composition, the cat will experience quite a strong burning sensation and pain at the injection site. If the concentrated medicine is “poured” directly into a vein (especially using the jet method), the cat may die from anaphylactic shock.
To dilute the drug, you must use only sterile solvents. It is also possible to use sterile distilled or boiled and filtered water. If the solvent contains even a small amount of glucose, it should not be used, as it can significantly reduce the effectiveness of the medicine.
Price and analogues
The cost of one Roncoleukin ampoule with a volume of 1 ml is calculated in accordance with the content of the active substance:
- 50,000 IU – costs 180-210 rubles
- 100,000 IU - will cost 240-270 rubles
- 250,000 IU – you can buy 330-370 rubles
- 500,000 IU - available for sale for 600-650 rubles
- 2000000 IU - has a price of 1600-1700 rubles
The cost of the drug may vary depending on economic conditions and region. As for analogues, today the drug closest to this medicine in terms of its characteristics and characteristics is Bioleukin, which also contains interleukin-2. But still, according to most experts, Roncoleukin remains preferable in terms of treating pathologies in pets.
Over the course of many years of experience, it was found that dogs of any age and breed tolerate this drug quite well, there are no side effects at all if the course of treatment is followed impeccably, and the effect is quite high and long-lasting.
