Frontline Nexgard for dogs 2-4 kg

Frontline Nexgard flea and tick chewable tablets for dogs

Chewable tablets for combating cutaneous ectoparasites “Frontline Nexgard” appeared on the Russian market in 2021 and immediately received positive reviews from veterinary experts .
The success of the drug was due to the possibility of its use not only for removing parasites from a dog’s body, but also for the treatment and prevention of infection (infestation) of an animal with fleas, ixodids, ear mites, and some other types of cutaneous eco- and endoparasites. Frontline Nexgard is available for dogs of different weights:

2-4 kg;
4.1-10 kg;
10.1-25 kg;
25.1-50 kg.

The release form of the drug is soft pink tablets with the taste and smell of stewed beef, round (0.5 g), oval or rectangular (1, 25, 3 and 6 g) for oral use.

The drug goes on sale in a cardboard box containing 1 blister with three or six tablets.

Frontline Nexgard protects the animal for 30 days. Shown:

puppies over 8 weeks of age;
adult dogs;
pregnant and lactating bitches.

Reference. Frontline Nexgard is safe for dog breeds with an altered drug sensitivity gene (MDR1). These breeds include all varieties of Collie, English, Australian, East European, German Shepherd, Afghan Hound, Cani Corso, Labrador, Old English Bulldog, Dachshund, Bobtail and some other breeds.

Operating principle

"Frontline Nexgard" belongs to the group of insectoacaricidal drugs with systemic action. Its active ingredient afoxolaner belongs to the group of latest generation insecticides - isoxazolines.

Afoxolaner contained in the drug, entering the dog’s stomach, dissolves, is absorbed into the gastrointestinal tract and enters the circulatory system.

When a dog is bitten by a parasite, the poison, along with the victim’s blood, enters the gastrointestinal tract of the ectoparasite, overexcites neurons and disrupts the passage of nerve impulses. This leads to paralysis of the nervous system and inevitable death of the arthropod.

Frontline Nexgard has a high impact rate on parasites. Fleas and ticks do not have time to lay eggs and introduce the pathogen with feces through wounds, microtraumas of the skin into the blood of the host animal, and also infect the premises. The first signs of parasite poisoning begin to appear 30 minutes after the bite. The death of fleas occurs after 6-8 hours, ticks after 12-48 hours.

Reference. The active ingredient afoxolaner breaks down slowly and is completely eliminated from the dog’s body through urine and bile after 3-4 weeks.

Pharmacological properties

Frontline Nexgard tablets are effective against Ctenocephalides fleas (C. felis and C. caninum) and ixodid ticks of 5 genera:

Ixodes – holocyclus, ricinus, scapularis;
Dermacentor - variabilis, reticulatus;
Haemaphysalis longicornis;
Rhipicephalus sanguineus;
Amblyomma americanum.

In addition, the drug is successfully used against certain types of skin mites, lice, and lice.

In veterinary medicine, the drug is used in the prevention and complex treatment of borreliosis, piroplasmosis, aphanipterosis, allergic dermatitis, acarosis, pulicosis, demodicosis, otodectosis, sarcoptic mange. Frontline Nexgard also helps prevent dogs from becoming infected with the flea-borne tapeworm Dipylidium caninum.

Attention! Ixodid (forest, pasture) ticks most often act as carriers of piroplasmosis, a dangerous disease that leads to disruption of the central nervous system. Without timely diagnosis and treatment, your pet will inevitably die from cerebral or pulmonary edema.

Advantages of the drug

Chewable tablets "Frontline Nexgard" have a number of undoubted advantages:

They have an attractive taste and smell for dogs, which allows them to be used as a treat. This feature greatly facilitates the procedure of feeding the required dose of the drug.
The tablets do not crumble when fed, which eliminates the loss of part of the drug.
They have a quick and long-lasting effect on parasites.
The drug does not cause an allergic reaction even in dogs that cannot tolerate antiparasitic agents contained in drops, sprays and collars.
The tablet is taken orally; after taking it, there is no need to limit your pet’s contact with people and other pets.
Swimming in ponds and washing the dog with shampoo do not reduce the activity of the active substance.
The drug is practically harmless to dogs and is classified as a low-hazard substance of hazard class IV according to GOST.
Does not have a local irritant effect, does not affect the development of the embryo, does not cause hereditary changes in the body (mutations).
The drug can be used simultaneously with other dosage forms (drops, sprays, collars that have repellent (repellent) properties, as well as with antibiotics, NSAIDs (non-steroidal anti-inflammatory drugs), anthelmintics, glucocorticoids, vaccines.

Important! The drug does not contain animal proteins. It can be given to animals suffering from food allergies.

Instructions for use

The dosage is calculated according to the formula - 2.5 mg of active substance per 1 kg of dog weight:

for puppies and dwarf dogs (2-4 kg) - 1 tablet weighing 0.5 g;
for small children (4.1-10 kg) – 1 tablet weighing 1.25 g;
for dogs of medium breeds (10.1-25 kg) – 1 tablet per 3 g;
for large breeds (25.1-50 kg) - 1 tablet per 6 g;
for giant ones (over 50 kg) - a complex of tablets calculated according to the formula.

Attention! Tablets must not be broken!

During the active season of ticks and other ectoparasites, the drug is given to the dog monthly. It is more convenient to choose a specific date of the month. In case of interruption of the course, the use of the drug begins with the previous dose according to a similar scheme. In winter, use can be interrupted.

Contraindications and side effects

Not a single drug, even the most innovative one, can suit everyone without exception. There are also contraindications for Frontline Nexgard; it should not be given to dogs:

those who are allergic to the components included in the drug;
with kidney and liver dysfunction;
puppies under 8 weeks old;
animals weighing less than 2 kg;
during and immediately after an infectious disease or exacerbation of a chronic one.

Pregnant and lactating dogs are given the drug under the supervision of a veterinarian.

Side effects of the drug are not observed if the dosage and dosage regimen are followed. The following symptoms indicate an overdose and too long use of the drug:

lack of appetite;
peeling, redness of the skin (erythema), appearing and disappearing spontaneously;
in rare cases, diarrhea, lethargy, drowsiness, vomiting.

If an attack of vomiting begins within 2 hours after administration, after it stops, the drug is fed again in the same dosage.

Important! When using the drug, you should follow the usual precautions in such cases. During the procedures you should not drink, eat or smoke. When finished, wash your hands thoroughly with soap. If an allergic reaction occurs, seek medical help.

Analogs

Among those similar to Frontline Nexgard in terms of impact and form of application are:

Nesgard Spectra is another innovative product developed in laboratories. The active ingredients are afoxolaner and milbemycin oxime. The combined antiparasitic drug protects against fleas, ticks, nematodes, and heartworm larvae.

"Bravecto" are chewable tablets manufactured by. Unlike Frontline, the drug kills parasites before they bite.

"Simparica" is an American drug from Zoetis Inc. The active substance is sarolaner. Effective against fleas, sarcoptoid, ixodid, demodectic and psoroptoid ticks.

Price

The price of Frontline Nexgard anti-tick tablets for dogs is quite high. Depending on the region and method of purchase (specialized store or online), the cost varies:

for dogs weighing 2-4 kg – 1315-1500 rubles;
4.1-10 kg - 1480-1600 rubles;
10.1-25 kg -1650-1900 rub;
25.1-50 kg - 1900-2100 rub.

Frontline NexgarD tablet 11.3 mg for dogs from 2 to 4 kg (3 tablets/pack)

I. General information Trade name of the medicinal product: Frontline NexGard. International nonproprietary name: afoxolaner.

Dosage form: tablets for oral use (chewable).

Frontline NexgarD is available in four dosages: tablets weighing 0.5; 1.25; 3.0 and 6.0 g, containing 2.27% afoxolaner as the active substance (respectively 11.3 mg; 28.3 mg; 68 mg and 136 mg per tablet), as well as excipients: corn starch - 25% , soy protein flour - 20%, additive with the aroma and taste of stewed beef - 20%, povidone K30 - 2.7%, macrogol 400 - 7.1%, macrogol 4000 - 6.3%, macrogol 15 hydroxystearate - 3, 1%, glycerol - 10%, medium chain triglyceride - 3.1%, potassium sorbate - 0.3%.

In appearance, the drug is tablets from light pink to dark pink with reddish-brown inclusions of round (tablets weighing 0.5 g) or rectangular (tablets weighing 1.25; 3; 6 g) shape.

Frontline NexgarD is produced packaged in 3 or 6 tablets in blisters made of polyvinyl chloride and aluminum foil on a paper base, packaged individually in a cardboard box along with instructions for use.

Store the medicinal product in the manufacturer's sealed packaging, separately from food and feed, in a place protected from direct sunlight, at a temperature from 0°C to 30°C.

The shelf life of the medicinal product, subject to storage conditions, is 24 months from the date of manufacture. It is prohibited to use the medicine after the expiration date.

Frontline NexGard should be kept out of the reach of children.

Unused medicinal product is disposed of in accordance with legal requirements.

II. Pharmacological properties Frontline NexgarD refers to insectoacaricidal drugs with systemic action. Afoxolaner, which is part of the drug, is an insectoacaricide of the isoxazoline group. The mechanism of action of afoxolaner is to block GABA-dependent arthropod receptors, hyperexcite neurons, disrupt the transmission of nerve impulses, which leads to paralysis and death of ectoparasites.

Frontline NexgarD is active against fleas Ctenocephalides felis, Ctenocephalides canis, as well as ixodid ticks Dermacentor variabilis, Dermacentor reticulatus, Rhipicephalus sanguineus, Ixodes scapularis, Ixodes ricinus, Ixodes holocyclus, Haemaphysalis longicornis, Amblyomma americanum. After oral administration of the drug, afoxolaner is easily absorbed from the gastrointestinal tract and reaches the systemic circulation, the maximum concentration in plasma is observed 2-4 hours after administration, bioavailability is 74%. Afoxolaner is slowly metabolized to form hydroxylated compounds and is excreted from the body mainly in bile and slightly in urine. The half-life of afoxolaner is 14 days.

The effect of the drug on fleas begins 30 minutes after administration; a single use of the drug ensures the destruction of fleas and ticks on an animal within 6 and 48 hours, respectively; prevents re-infection for 4 weeks. The death of fleas occurs before laying eggs, which prevents contamination of premises with eggs and larvae.

In terms of the degree of impact on the body, Frontline NexgarD is a low-hazard substance (hazard class 4 according to GOST 12.1.007-76), in recommended doses it does not have teratogenic, embryotoxic, mutagenic properties, and does not have a local irritant effect.

III. Directions for use Frontline NexgarD is prescribed to dogs for the treatment and prevention of aphanipterosis, in the complex therapy of allergic dermatitis caused by fleas, as well as acarosis caused by ixodid ticks.

A contraindication to the use of NexgarD is the increased individual sensitivity of the animal to the components of the drug, severe impairment of liver and kidney function. The drug should not be used by patients with infectious diseases and weakened animals, puppies under 8 weeks of age and/or weighing less than 2 kg, as well as animals of other species. Pregnant and lactating females, if necessary, use Frontline NexgarD under the supervision of a veterinarian.

Frontline NexgarD is administered to dogs individually orally once at a minimum dose of 2.5 mg of afoxolaner per 1 kg of animal weight in accordance with the table:

Dog weight, kg	Tablet weight, grams	Dose of active substance, mg/tab.
2-4	0,5	11,3
4,1-10	1,25	28,3
10,1-25	3,0	68,0
25,1-50	6,0	136,0

When using the drug in dogs weighing more than 50 kg, a combination of tablets should be used at the rate of 2.5 mg of afoxolaner per 1 kg of weight. Breaking tablets is not allowed.

Frontline Nexgard has an attractive aroma and taste and, as a rule, is readily eaten by dogs; otherwise, the drug is fed mixed with food. Make sure that the dog has completely swallowed the required dose of the drug. Repeated treatments during the season of greatest ectoparasite activity are carried out monthly.

In case of an overdose of the drug, the animal may experience a decrease in appetite and body weight gain, as well as skin changes (erythema, peeling) that disappear spontaneously.

No specific effects of the drug during its first use and discontinuation were identified.

Violations of the drug use regimen should be avoided, as this may lead to a decrease in its effectiveness. If the next treatment is missed, the use of the drug should be resumed at the same dose and according to the same regimen.

When using the drug in accordance with these instructions, side effects and complications in animals, as a rule, are not observed . With long-term use of the drug, a decrease in appetite and spontaneously disappearing skin changes (erythema, peeling) are possible; rarely - vomiting, diarrhea and drowsiness. If the dog vomits within the first two hours after taking Frontline NexgarD, it is recommended to give the drug again at the same dose.

With the simultaneous use of Frontline NexgarD with anthelmintic drugs, antibiotics, vaccines, glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs), no adverse reactions or decrease in the effectiveness of the drug were detected.

Frontline NexGard is not intended for use in food producing animals.

IV.Personal preventive measures During work, smoking, drinking and eating are prohibited. After handling the medicine, you should wash your hands with soap.

People with hypersensitivity to the components of the drug should avoid direct contact with the drug. In case of allergic reactions or if Frontline NexgarD accidentally enters the human body, you should immediately contact a medical facility, having with you the label or instructions for use of the drug.

It is prohibited to use empty medicinal product packaging for household purposes; it is placed in a plastic bag and disposed of with household waste.

Anti-tick tablets for dogs "Frontline Nexgard": reviews

From dog owners

We tried Frontline Nesgard on the advice of a doctor. Our teammate’s dog died from incorrectly selected drops. They gave it with caution, but everything worked out. About five ticks were removed during the season. Already dead. There were no consequences. Thanks to our doctor and the French for a good drug.

Veronica Smyslova

The drug is good. The tick bites and dies (the price, however, also bites). I’m not worried about the health of my Chara. There was vomiting once, but it went away quickly. They gave the pill a second time and did not regret it. He eats pills with pleasure. If it were up to her, she would gobble up the entire package at once. Very easy to use and reliable.

Irina Mordvinova

I have a working husky. We often go hunting. I have been looking for a “non-breakable” drug for a long time with others. Hunter friends recommended French chewable tablets. I tried it and liked it. I use it almost all year round. At the same time, I treat the dog with a spray; tablets alone are not enough.

Victor Antropov

From veterinarians

Often in my practice I encounter illiteracy among dog breeders. Recently, a Spitz owner removed a tick from her dog after taking Frontline Nesgard and threw a tantrum at the doctors. Ladies and Gentlemen! The drug is reliable and has proven itself, but it does not repel ticks. He kills them after biting them! Read the instructions carefully.

Kirill Maksimov

I use Frontline Nesgard in combination to treat allergic dermatitis, demodicosis, and otodectosis. The dynamics are positive. The medicine is reliable, high-quality, and has passed many clinical trials. Has more than five times the overdose protection. Therefore, I calmly recommend it to the owners of my patients.

Rinat Bikbatulin

I used to use Bravecto in my practice, but after getting acquainted with Frontline I switched to it. The tablet is smaller in size, more convenient to give, and dogs like it more than other “chews.” You can give it with or without food, which is also very convenient. True, Bravecto lasts longer, but its cost is 3 times more, which is also not in its favor.

Vera Nikitina

Chewable tablets "Frontline Nesgard" in a short time acquired a reputation as a high-quality and effective drug. The innovative formula, safety for dogs, carrying out the procedure without unnecessary hassle, guaranteed results, and the ability to prevent many dangerous diseases allow us to speak of Frontline as one of the best modern antiparasitic drugs.